Man's Best Friend is a 1993 American horror film, written and directed by John Lafia. It stars Ally Sheedy as a TV personality who adopts a genetically altered Tibetan Mastiff, and Lance Henriksen as a mad scientist who tries to track down his dog after he goes missing. It was released on November 19, 1993. The official tagline was "Nature created him. Science perfected him. But no one can control him."
Judy Sanders (Robin Frates), who works in a research facility, has contacted TV personality Lori Tanner (Ally Sheedy). The plan was for them to meet after work. Judy is going to let Lori into the research facility to show her the atrocities that go on behind closed doors at EMAX. Dr. Jarret (Lance Henriksen), who is doing vivisection and genetic altering, discovers the plan and Judy is killed by one of his experiments. Laurie keeps her appointment, but when Judy does not show, she decides to break into the lab where she finds and films dead bodies and animals that are in the middle of research projects. Among them is a Tibetan Mastiff named Max (the same one who killed Judy), who has been genetically altered with big cats and other exotic animals. While shooting the lab scene, Max
(This is information generated from a Wikipedia article, licensed under the GNU Free Documentation License.)