50/50 is a 2011 comedy-drama film directed by Jonathan Levine, written by Will Reiser, and starring Joseph Gordon-Levitt and Seth Rogen. The film is loosely inspired by Reiser's own experience with cancer.
Adam Lerner (Joseph Gordon-Levitt) is a 27-year-old public radio journalist with an artist girlfriend Rachael (Bryce Dallas Howard), of whom his best friend and co-worker Kyle (Seth Rogen) disapproves.
Adam discovers he has a rare cancer in his spine and must undergo chemotherapy. He sees on the Internet that his chances of survival are 50/50. After Adam reveals his diagnosis, his overbearing mother, Diane (Anjelica Huston), who already cares for a husband suffering from dementia, wants to move in and care for him. Adam rejects this offer, however, as Rachael has promised to be the one to take care of him. However, Rachael is uncomfortable going into the hospital during Adam's chemo treatments. Later, Kyle sees Rachael kissing another man and tells Adam that Rachael is cheating on him. Adam and Rachael break up. Kyle attempts to keep Adam's spirits high, which include helping Adam shave his head prior to chemotherapy and suggesting that Adam use his illness as a way to pick up
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50/50 is an upcoming comedy drama film directed by Jonathan Levine, starring Joseph Gordon-Levitt, Anna Kendrick, Seth Rogen, Bryce Dallas Howard and Anjelica Huston.